![]() ![]() We recommend that, regardless of ingested dose, all patients presenting within 24 h of nonstaggered acetaminophen overdose should have their plasma acetaminophen concentration determined.Ī lower treatment line (the '100-line'), which joins an acetaminophen concentration of 100 mg/l at 4 h with one of 15 mg/l at 15 h, is widely used for patients in one of two high-risk groups : conditions that lead to decreased hepatic glutathione (e.g. The hepatotoxic dose of acetaminophen is generally accepted to be 150 mg/kg, although the evidence for this is far from strong. The nomograms are less reliable in patients who present late (more than 15 h after ingestion), and patients with an acetaminophen concentration just below the line should also receive treatment. All of these are based on the Prescott nomogram, in which a line is drawn that joins an acetaminophen concentration of 200 mg/l at 4 h and one of 30 mg/l at 15 h (the '200-line'). A number of treatment nomograms are in use worldwide. Management of patients presenting within 24 h of nonstaggered overdose is guided by the plasma acetaminophen concentration, plotted against time since ingestion on a treatment nomogram. It provides complete protection against hepatotoxicity if given within 12 h of nonstaggered overdose. ![]() The antidote for acetaminophen poisoning is N-acetylcysteine (NAC). ![]()
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